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Tag nrf2 [81 articles]

Recent papers classified by the tag nrf2.
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  • DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.
    Proc Natl Acad Sci U S A, Vol. 103, No. 41. (10 October 2006), pp. 15091-15096.
    by CM Clements, RS McNally, BJ Conti, TW Mak, JP Ting
  • Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice.
    J Exp Med, Vol. 202, No. 1. (4 July 2005), pp. 47-59.
    by T Rangasamy, J Guo, WA Mitzner, J Roman, A Singh, AD Fryer, M Yamamoto, TW Kensler, RM Tuder, SN Georas, S Biswal
    posted to asthma hyperresponsiveness inflammation nrf2 by Yulquz on 2008-02-16 22:47:18 as **
  • Molecular pathogenesis of emphysema.
    J Clin Invest, Vol. 118, No. 2. (February 2008), pp. 394-402.
    posted to nrf2 sirt1 by Yulquz on 2008-02-09 23:56:14 as ***
  • Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury
    FASEB J., Vol. 20, No. 14. (1 December 2006), pp. 2624-2626.
    by Martin O Leonard, Niamh E Kieran, Katherine Howell, Melissa J Burne, Raghu Varadarajan, Saravanakumar Dhakshinamoorthy, Alan G Porter, Cliona O'Farrelly, Hamid Rabb, Cormac T Taylor
  • Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.
    Circ Res, Vol. 101, No. 7. (28 September 2007), pp. 723-733.
    by G Dai, S Vaughn, Y Zhang, ET Wang, G Garcia-Cardena, MA Gimbrone
    posted to akt atheroprotective atherosclerosis nrf2 oxidative pi3k protect redox shear by tsjipko on 2007-10-22 10:52:36 as **
  • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
    Cancer research, Vol. 62, No. 18. (15 September 2002), pp. 5196-5203.
    by RK Thimmulappa, KH Mai, S Srisuma, TW Kensler, M Yamamoto, S Biswal
    posted to pathway nrf2 by oelemento on 2008-11-29 18:11:27 as **
  • The transcription factor NRF2 protects against pulmonary fibrosis
    FASEB J. (18 June 2004), 03-1127fje.
    by Hye-Youn Cho, Sekhar P Reddy, Masayuki Yamamoto, Steven R Kleeberger
    posted to nrf2 antioxidant_response_element by oelemento on 2008-09-30 16:24:16 as **
  • Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 16, No. 9. (September 2007), pp. 1784-1794.
    by CC Hong, CB Ambrosone, J Ahn, JY Choi, ML McCullough, VL Stevens, C Rodriguez, MJ Thun, EE Calle
    posted to nrf2 nqo1 nos3 iron ho1 genetics breast acs by misonneh on 2008-09-24 20:10:40 as read
  • Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.
    Free Radic Biol Med, Vol. 37, No. 10. (15 November 2004), pp. 1578-1590.
    by C Chen, D Pung, V Leong, V Hebbar, G Shen, S Nair, W Li, AN Kong
    posted to antioxidants are cytochrome-p450 detoxification mapkgarlic nrf2 by imouthesmp on 2005-12-09 00:51:48 as ****
  • Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts.
    Ann N Y Acad Sci, Vol. 1067 (May 2006), pp. 420-424.
    by DC Kraft, CC Deocaris, R Wadhwa, SI Rattan
    posted to aging autophagy hannink nrf2 proteasome by imouthesmp on 2006-09-08 14:01:01 as **
  • Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.
    J Agric Food Chem, Vol. 54, No. 5. (8 March 2006), pp. 1656-1662.
    posted to aging hannink nf-kb nrf2 oxidative-stress sulforaphane by imouthesmp on 2006-08-21 18:17:53 as **
  • Cloning and characterization of the human glutathione synthetase 5'-flanking region.
    Biochem J, Vol. 390, No. Pt 2. (1 September 2005), pp. 521-528.
    by TD Lee, H Yang, J Whang, SC Lu
    posted to aging are glutathione nrf2 oxidative-stress ps by imouthesmp on 2005-12-12 00:16:36 as ***
  • Gene expression profiling of NRF2-mediated protection against oxidative injury.
    Free Radic Biol Med, Vol. 38, No. 3. (1 February 2005), pp. 325-343.
    by HY Cho, SP Reddy, A Debiase, M Yamamoto, SR Kleeberger
  • Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.
    Mol Cancer Ther, Vol. 5, No. 8. (August 2006), pp. 1918-1926.
    by C Xu, X Yuan, Z Pan, G Shen, JH Kim, S Yu, TO Khor, W Li, J Ma, AN Kong
    posted to are erk hannink jnk nrf2 by imouthesmp on 2006-09-03 04:22:25 as **
  • Transcription Factor Nrf2 Protects the Brain From Damage Produced by Intracerebral Hemorrhage
    Stroke, Vol. 38, No. 12. (1 December 2007), pp. 3280-3286.
    by Xiurong Zhao, Guanghua Sun, Jie Zhang, Roger Strong, Pramod K Dash, Yuet W Kan, James C Grotta, Jaroslaw Aronowski
  • Ni(II) activates the Nrf2 signaling pathway in human monocytic cells
    Biomaterials, Vol. 27, No. 31. (November 2006), pp. 5348-5356.
    by J Lewis, R Messer, V Mccloud, P Lockwood, S Hsu, J Wataha
  • Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
    Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 49. (4 December 2007), pp. 19589-19594.
    by XJ Wang, JD Hayes, CJ Henderson, CR Wolf
  • Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
    Am J Physiol Heart Circ Physiol, Vol. 290, No. 5. (1 May 2006), pp. H1862-1870.
    by Xi-Lin Chen, Geraldine Dodd, Suzanne Thomas, Xiaolan Zhang, Martin A Wasserman, Brad H Rovin, Charles Kunsch
  • Essential Roles of the PI3 Kinase/Akt Pathway in Regulating Nrf2-Dependent Antioxidant Functions in the RPE
    Invest. Ophthalmol. Vis. Sci., Vol. 49, No. 4. (1 April 2008), pp. 1671-1678.
    by Ling Wang, Yan Chen, Paul Sternberg, Jiyang Cai
  • Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes.
    Journal of molecular and cellular cardiology (1 November 2008)
    by Xiaoqing He, Hong Kan, Lu Cai, Qiang Ma
  • Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
    Am J Physiol Endocrinol Metab, Vol. 293, No. 3. (1 September 2007), pp. E645-655.
    by Subbiah Pugazhenthi, Leonid Akhov, Gopalan Selvaraj, Maorong Wang, Jawed Alam
  • Enhancing Expression of Nrf2-Driven Genes Protects the Blood Brain Barrier after Brain Injury
    J. Neurosci., Vol. 27, No. 38. (19 September 2007), pp. 10240-10248.
    by Jing Zhao, Anthony N Moore, John B Redell, Pramod K Dash
  • Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis.
    Journal of neuropathology and experimental neurology, Vol. 67, No. 11. (November 2008), pp. 1055-1062.
  • From the Cover: Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
    Proceedings of the National Academy of Sciences, Vol. 105, No. 7. (19 February 2008), pp. 2325-2330.
    by Kevin J Pearson, Kaitlyn N Lewis, Nathan L Price, Joy W Chang, Evelyn Perez, Maria V Cascajo, Kellie L Tamashiro, Suresh Poosala, Anna Csiszar, Zoltan Ungvari, Thomas W Kensler, Masayuki Yamamoto, Josephine M Egan, Dan L Longo, Donald K Ingram, Placido Navas, Rafael de Cabo
  • Mitochondrial Superoxide Production and Nuclear Factor Erythroid 2-Related Factor 2 Activation in p75 Neurotrophin Receptor-Induced Motor Neuron Apoptosis
    J. Neurosci., Vol. 27, No. 29. (18 July 2007), pp. 7777-7785.
    by Mariana Pehar, Marcelo R Vargas, Kristine M Robinson, Patricia Cassina, Pablo J Diaz-Amarilla, Tory M Hagen, Rafael Radi, Luis Barbeito, Joseph S Beckman
  • Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide.
    Experimental cell research, Vol. 290, No. 2. (1 November 2003), pp. 234-245.
    by J Pi, W Qu, JM Reece, Y Kumagai, MP Waalkes
  • Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.
    The Journal of allergy and clinical immunology, Vol. 121, No. 5. (May 2008)
    by HJ Kim, B Barajas, M Wang, AE Nel
  • Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts
    Biochemical and Biophysical Research Communications, Vol. 310, No. 3. (24 October 2003), pp. 824-829.
  • notes Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
    The Journal of clinical investigation, Vol. 116, No. 4. (April 2006), pp. 984-995.
  • Role of Nrf2 in Protection against Traumatic Brain Injury in Mice
    Journal of Neurotrauma, Vol. 0, No. 0. (0)
    by Wei Jin, Handong Wang, Wei Yan, Lin Zhu, Zhigang Hu, Yasuo Ding, Ke Tang
  • Nrf2 gene promoter polymorphism and gastric carcinogenesis.
    Hepato-gastroenterology, Vol. 55, No. 82-83. (r 2008), pp. 750-754.
  • Modulation of Nrf2-Dependent Antioxidant Functions in the RPE by Zip2, a Zinc Transporter Protein
    Invest. Ophthalmol. Vis. Sci., Vol. 49, No. 4. (1 April 2008), pp. 1665-1670.
    by Kasra A Rezaei, Yan Chen, Jiyang Cai, Paul Sternberg
  • Functional expression of beta<SUB><FONT SIZE='-1'>2</FONT></SUB> adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells
    Journal of Cellular Physiology, Vol. 218, No. 2. (2009), pp. 268-275.
    by Yoshifumi Takahata, Takeshi Takarada, Mika Iemata, Tomomi Yamamoto, Yukary Nakamura, Ayumi Kodama, Yukio Yoneda
  • Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.
    Toxicological sciences : an official journal of the Society of Toxicology, Vol. 106, No. 2. (December 2008), pp. 319-328.
    by JM Maher, LM Aleksunes, MZ Dieter, Y Tanaka, JM Peters, JE Manautou, CD Klaassen
  • Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis☆
    Biochemical Pharmacology, Vol. 76, No. 11. (01 December 2008), pp. 1485-1489.
    by W Li, T Khor, C Xu, G Shen, W Jeong, S Yu, A Kong
  • NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis.
    Current neurovascular research, Vol. 3, No. 4. (November 2006), pp. 249-261.
    by M Okouchi, N Okayama, JS Alexander, TY Aw
  • Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention.
    Biochem Pharmacol, Vol. 72, No. 7. (28 September 2006), pp. 795-805.
    by C Köhle, KW Bock
  • Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
    Proceedings of the National Academy of Sciences, Vol. 106, No. 1. (6 January 2009), pp. 250-255.
    by Thomas E Sussan, Tirumalai Rangasamy, David J Blake, Deepti Malhotra, Hazim El-Haddad, Djahida Bedja, Melinda S Yates, Ponvijay Kombairaju, Masayuki Yamamoto, Karen T Liby, Michael B Sporn, Kathleen L Gabrielson, Hunter C Champion, Rubin M Tuder, Thomas W Kensler, Shyam Biswal
  • Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells
    International Journal of Cancer, Vol. 123, No. 6. (2008), pp. 1262-1268.
    by Fuzhi Lian, Xiang-Dong Wang
  • Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.
    Genes Cells, Vol. 8, No. 4. (April 2003), pp. 379-391.
  • Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages.
    The Journal of biological chemistry, Vol. 275, No. 21. (26 May 2000), pp. 16023-16029.
    by T Ishii, K Itoh, S Takahashi, H Sato, T Yanagawa, Y Katoh, S Bannai, M Yamamoto
  • Nrf1 and Nrf2 Regulate Rat Glutamate-Cysteine Ligase Catalytic Subunit Transcription Indirectly via NF-kappaB and AP-1
    Mol. Cell. Biol., Vol. 25, No. 14. (15 July 2005), pp. 5933-5946.
    by Heping Yang, Nathaniel Magilnick, Candy Lee, Denise Kalmaz, Xiaopeng Ou, Jefferson Y Chan, Shelly C Lu
  • Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.
    Free radical biology & medicine, Vol. 43, No. 4. (15 August 2007), pp. 535-545.
    by ES Kang, IS Woo, HJ Kim, SY Eun, KS Paek, HJ Kim, KC Chang, JH Lee, HT Lee, JH Kim, T Nishinaka, C Yabe-Nishimura, HG Seo
  • Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.
    Biochemical pharmacology, Vol. 73, No. 12. (15 June 2007), pp. 1853-1862.
    by C Köhle, KW Bock
  • Methylmercury Toxicity and Nrf2-dependent Detoxification in Astrocytes
    Toxicol. Sci., Vol. 107, No. 1. (1 January 2009), pp. 135-143.
    by Ling Wang, Haiyan Jiang, Zhaobao Yin, Michael Aschner, Jiyang Cai
  • Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.
    American journal of respiratory and critical care medicine, Vol. 178, No. 6. (15 September 2008), pp. 592-604.
  • Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity.
    Toxicological sciences : an official journal of the Society of Toxicology, Vol. 96, No. 1. (March 2007), pp. 30-39.
  • (−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells
    Archives of Biochemistry and Biophysics, Vol. 476, No. 2. (15 August 2008), pp. 171-177.
    by H Na, E Kim, J Jung, H Lee, J Hyun, Y Surh
  • Dopamine activates Nrf2-regulated neuroprotective pathways in astrocytes and meningeal cells
    Journal of Neurochemistry, Vol. 101, No. 1. (April 2007), pp. 109-119.
  • Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG
    Food and Chemical Toxicology, Vol. 46, No. 4. (April 2008), pp. 1271-1278.
    by H Na, Y Surh
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