Cocaine conditioning: Reversal by autoreceptor dose levels of 8-OHDPAT.

@article{citeulike:3322442, abstract = {In order to investigate the contribution of serotonergic effects of cocaine to Pavlovian conditioning of cocaine locomotor stimulant effects, two experiments were conducted in which groups of rats (N=10) received cocaine treatments (10 mg/kg) paired or unpaired to placement in an open-field environment. Initially, a cocaine conditioned locomotion stimulant effect was established. Next, additional Coc-P and Coc-UP pairings were carried out in conjunction with pretreatment injections of the 5-HT(1A) agonist, 8-OHDPAT (0.01, 0.025 and 0.05 mg/kg) or saline. In experiment 1, the Coc-P group which received the saline pretreatment again exhibited conditioning but in the 8-OHDPAT pretreatment Coc-P group conditioning was eliminated. In the second experiment, the protocol of the first experiment was repeated but expanded in the post-conditioning phase to include an 8-OHDPAT plus the 5-HT(1A) antagonist pretreatment Coc-P group. As in the first experiment, the 8-OHDPAT pretreatment Coc-P group did not exhibit a cocaine conditioned locomotion stimulant effect; whereas, the saline pretreatment Coc-P and the 8-OHDPAT plus WAY-100635 pretreatment Coc-P groups did exhibit the cocaine conditioned locomotion stimulant effect. These findings are consistent with an important role for serotonin in the maintenance of cocaine Pavlovian conditioned effects.}, address = {Research Service (151), VA Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA; SUNY Upstate Medical University, Syracuse, NY 13210, USA.}, author = {Carey, Robert J J. and Damianopoulos, Ernest N N. and Shanahan, Arielle B B. }, citeulike-article-id = {3322442}, doi = {http://dx.doi.org/10.1016/j.pbb.2008.08.027}, issn = {0091-3057}, journal = {Pharmacology, biochemistry, and behavior}, month = {September}, posted-at = {2008-09-23 16:51:51}, priority = {2}, title = {Cocaine conditioning: Reversal by autoreceptor dose levels of 8-OHDPAT.}, url = {http://dx.doi.org/10.1016/j.pbb.2008.08.027}, year = {2008} }

TY - JOUR ID - citeulike:3322442 L3 - citeulike-article-id:3322442 N2 - In order to investigate the contribution of serotonergic effects of cocaine to Pavlovian conditioning of cocaine locomotor stimulant effects, two experiments were conducted in which groups of rats (N=10) received cocaine treatments (10 mg/kg) paired or unpaired to placement in an open-field environment. Initially, a cocaine conditioned locomotion stimulant effect was established. Next, additional Coc-P and Coc-UP pairings were carried out in conjunction with pretreatment injections of the 5-HT(1A) agonist, 8-OHDPAT (0.01, 0.025 and 0.05 mg/kg) or saline. In experiment 1, the Coc-P group which received the saline pretreatment again exhibited conditioning but in the 8-OHDPAT pretreatment Coc-P group conditioning was eliminated. In the second experiment, the protocol of the first experiment was repeated but expanded in the post-conditioning phase to include an 8-OHDPAT plus the 5-HT(1A) antagonist pretreatment Coc-P group. As in the first experiment, the 8-OHDPAT pretreatment Coc-P group did not exhibit a cocaine conditioned locomotion stimulant effect; whereas, the saline pretreatment Coc-P and the 8-OHDPAT plus WAY-100635 pretreatment Coc-P groups did exhibit the cocaine conditioned locomotion stimulant effect. These findings are consistent with an important role for serotonin in the maintenance of cocaine Pavlovian conditioned effects. JF - Pharmacology, biochemistry, and behavior SN - 0091-3057 AD - Research Service (151), VA Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA; SUNY Upstate Medical University, Syracuse, NY 13210, USA. TI - Cocaine conditioning: Reversal by autoreceptor dose levels of 8-OHDPAT. AU - Carey, Robert J AU - Damianopoulos, Ernest N AU - Shanahan, Arielle B PY - 2008/09/09/ UR - http://dx.doi.org/10.1016/j.pbb.2008.08.027 ER -