Individual differences in initial low-dose cocaine-induced locomotor activity and locomotor sensitization in adult outbred female Sprague-Dawley rats.

@article{citeulike:3352588, abstract = {Sex and individual differences are important considerations when studying cocaine responsiveness. We have previously shown that male Sprague-Dawley (S-D) rats can be classified as low or high cocaine responders (LCRs or HCRs, respectively) based on their locomotor activity following a single dose of cocaine (10 mg/kg, i.p.). Further, this distinction was found to predict dopamine transporter function, cocaine-induced locomotor sensitization, cocaine conditioned place preference and motivation to self-administer cocaine. Here we investigated whether or not individual differences in cocaine-induced locomotor activity and locomotor sensitization exist in female S-D rats. Female rats exhibited a broad range of locomotor activation following either a 5 or 10 mg/kg cocaine injection, allowing for classification as LCRs or HCRs. When administered over 7 days, both doses induced locomotor sensitization in female LCRs/HCRs. However, the magnitude of effects produced by 5 mg/kg cocaine in female LCRs/HCRs was more comparable to that produced by 10 mg/kg in male LCRs/HCRs, both of which, interestingly, developed sensitization in this study. These findings suggest that female S-D rats, like male S-D rats, can be classified as LCRs/HCRs and highlight the importance of accounting for dose when studying sex and individual differences to the effects of cocaine.}, address = {University of Colorado Denver, School of Medicine, Department of Pharmacology, Aurora, CO, United States.}, author = {Mandt, Bruce H H. and Allen, Richard M M. and Zahniser, Nancy R R. }, citeulike-article-id = {3352588}, doi = {http://dx.doi.org/10.1016/j.pbb.2008.09.002}, issn = {0091-3057}, journal = {Pharmacology, biochemistry, and behavior}, month = {September}, posted-at = {2008-09-29 13:27:00}, priority = {2}, title = {Individual differences in initial low-dose cocaine-induced locomotor activity and locomotor sensitization in adult outbred female Sprague-Dawley rats.}, url = {http://dx.doi.org/10.1016/j.pbb.2008.09.002}, year = {2008} }

TY - JOUR ID - citeulike:3352588 L3 - citeulike-article-id:3352588 N2 - Sex and individual differences are important considerations when studying cocaine responsiveness. We have previously shown that male Sprague-Dawley (S-D) rats can be classified as low or high cocaine responders (LCRs or HCRs, respectively) based on their locomotor activity following a single dose of cocaine (10 mg/kg, i.p.). Further, this distinction was found to predict dopamine transporter function, cocaine-induced locomotor sensitization, cocaine conditioned place preference and motivation to self-administer cocaine. Here we investigated whether or not individual differences in cocaine-induced locomotor activity and locomotor sensitization exist in female S-D rats. Female rats exhibited a broad range of locomotor activation following either a 5 or 10 mg/kg cocaine injection, allowing for classification as LCRs or HCRs. When administered over 7 days, both doses induced locomotor sensitization in female LCRs/HCRs. However, the magnitude of effects produced by 5 mg/kg cocaine in female LCRs/HCRs was more comparable to that produced by 10 mg/kg in male LCRs/HCRs, both of which, interestingly, developed sensitization in this study. These findings suggest that female S-D rats, like male S-D rats, can be classified as LCRs/HCRs and highlight the importance of accounting for dose when studying sex and individual differences to the effects of cocaine. JF - Pharmacology, biochemistry, and behavior SN - 0091-3057 AD - University of Colorado Denver, School of Medicine, Department of Pharmacology, Aurora, CO, United States. TI - Individual differences in initial low-dose cocaine-induced locomotor activity and locomotor sensitization in adult outbred female Sprague-Dawley rats. AU - Mandt, Bruce H AU - Allen, Richard M AU - Zahniser, Nancy R PY - 2008/09/10/ UR - http://dx.doi.org/10.1016/j.pbb.2008.09.002 ER -